Brian embarks on his first FBI field assignment to lend his skills to the bureau unit that catches serial killers, he soon realizes they have put away an innocent man; Meanwhile, Brian gets a third bodyguard and tries to stop Rebecca from discovering Senator Morra's connection to NZT.
- Tate Donovan as John
- Colin Salmon as Mr. Sands
- Gbenga Akinnagbe as Quentin Walker
- Susan Kelechi Watson as Elo / Eloise Carlisle
- Stephen O'Reilly as Agent "Spike"
- Michael Devine as James "Tech" Padgett
- Julee Cerda as Gerd Rep
- Gian-Murray Gianino as The Scrub Jay
- Edward Chin-Lyn as Agent "Spike One"
- Patrick Cooley as Agent "Spike Two"
- James Lloyd Reynolds as Gerard Turmann
- Jeremy Burnett as Jesse Escanso (Evidence Control Agent)
- Unknown actor as Bill Cumber
- Unknown actor as Peter Tao
- Unknown actor as Grayson Dumont
- Unknown actress as Catharine Lewis
- Unknown actor as Winton Miller